Polyclonal Antibody to Bub3 (Phospho-Tyr207), Rabbit
Biozol Catalog Number:
ABI-35-1351
Supplier Catalog Number:
35-1351
Alternative Catalog Number:
ABI-35-1351-100UL
Manufacturer:
Abeomics
Host:
Rabbit
Category:
Antikörper
Application:
WB
Species Reactivity:
Human, Mouse, Rat
Immunogen:
Peptide sequence around phosphorylation site of Tyrosine 207 (V-E-Y(p)-L-D) derived from Human Bub3.
Alternative Names:
Mitotic checkpoint protein BUB3||Hbub3||BUB3L||BUB3 budding uninhibited by benzimidazoles 3 homolog||budding uninhibited by benomyl
Has a dual function in spindle-assembly checkpoint signaling and in promoting the establishment of correct kinetochore-microtubule (K-MT) attachments. Promotes the formation of stable end-on bipolar attachments. Necessary for kinetochore localization of BUB1. Regulates chromosome segregation during oocyte meiosis. The BUB1/BUB3 complex plays a role in the inhibition of anaphase-promoting complex or cyclosome (APC/C) when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20. This complex can also phosphorylate MAD1L1.
