Peptide sequence around aa.1052~1056 (H-E-Y-Y-R) derived from Human TYK2.
Alternative Names:
tyrosine kinase 2|| JTK1
TYK2 encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E. Zheng H, et al. (2005) Mol Cell Proteomics. 4(6):721-730. Gauzzi MC, et al. (1996) J Biol Chem. 271(34): 20494-20500.
