Peptide sequence around aa. 195~199 (A-A-S-M-D) derived from Human AFX.
Alternative Names:
AFX|| FOXO4|| AFX1|| Afxh
Transcription factor involved in the regulation of the insulin signaling pathway. Binds to insulin-response elements (IREs) and can activate transcription of IGFBP1. Down-regulates expression of HIF1A and suppresses hypoxia-induced transcriptional activation of HIF1A-modulated genes. Also involved in negative regulation of the cell cycle.
