Peptide sequence around aa.878~882 (I-E-S-V-K) derived from Human Glutamate receptor 2.
Alternative Names:
GRIA2|| GluR-2|| GluR-B|| GluR-K2|| AMPA 2
Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. Cull-Candy, S. et al. (2006) Curr. Opin. Neurobiol. 16, 288-297. Hanley JG, et al. (2002) Neuron. 34(1): 53-67
