Peptide sequence around aa.303~307 (L-D-V-Y-S) derived from Human TFE3.
Alternative Names:
BHLHE33|| TFEA|| RCCP2
Transcription factor that specifically recognizes and binds E-box sequences (3-CANNTG-5). Efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFEB or MITF. In association with TFEB, activates the expression of CD40L in T-cells, thereby playing a role in T-cell-dependent antibody responses in activated CD4+ T-cells and thymus-dependent humoral immunity. Specifically recognizes the MUE3 box, a subset of E-boxes, present in the immunoglobulin enhancer. It also binds very well to a USF/MLTF site. Clark J., Lu Y.-J., Sidhar S.K., Parker C., Gill S. Oncogene 15:2233-2239(1997) Weterman M.A.J., Wilbrink M., Proc. Natl. Acad. Sci. U.S.A. 93:15294-15298(1996)
