Polyclonal Antibody to beta-Catenin (p120), Rabbit
Biozol Catalog Number:
ABI-36-1075
Supplier Catalog Number:
36-1075
Alternative Catalog Number:
ABI-36-1075-100UG
Manufacturer:
Abeomics
Host:
Rabbit
Category:
Antikörper
Application:
FACS, IHC, WB
Species Reactivity:
Human, Mouse
Immunogen:
A synthetic peptide from the middle of beta-Catenin (p120) protein
Alternative Names:
CTNNB1||CTNNB||OK/SW-cl.35||PRO2286
Beta-catenin associates with the cytoplasmic portion of E-cadherin, which is necessary for the function of E-cadherin as an adhesion molecule. In normal tissues, beta-catenin is localized to the membrane of epithelial cells, consistent with its role in the cell adhesion complex. In breast ductal neoplasia, beta-catenin is usually localized in cellular membranes. However, in lobular neoplasia, a marked redistribution of beta-catenin throughout the cytoplasm results in a diffuse cytoplasmic pattern. Immuno-staining of beta-catenin and E-cadherin is helps in the accurate identification of ductal and lobular neoplasms, including a distinction between low-grade ductal carcinoma in situ (DCIS) and lobular carcinoma. Additionally, some rectal and gastric adenocarcinomas demonstrate diffuse cytoplasmic beta-catenin staining and a lack of membranous staining, mimicking the staining pattern observed with lobular breast carcinomas.
Flow Cytometry (0.5-1ug/million cells), Western Blot (1-2ug/ml), Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 1mM EDTA, pH 9.0, for 45 min at 95&degC follo
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