Monoclonal Antibody to CD53 (TSPAN25)(Clone : 63-5A3), Clone: [63-5A3], Mouse
Biozol Catalog Number:
ABI-36-1949
Supplier Catalog Number:
36-1949
Alternative Catalog Number:
ABI-36-1949-100UG
Manufacturer:
Abeomics
Host:
Mouse
Category:
Antikörper
Application:
FA, FACS, IF
Species Reactivity:
Human
Immunogen:
Human Sezary cells
Alternative Names:
CD53||MOX44||TSPAN25
Recognizes a protein of 33-55kDa, identified as CD53 (Workshop V, Code CD53.1). CD53 is expressed on monocytes, and macrophages, granulocytes, dendritic cells, osteoblasts and osteoclasts, NK cells, and on T- and B-cells from every stage of differentiation but is absent from platelets, erythrocytes, and non-haemopoietic cells. CD53 is a member of a family of tetraspan transmembrane proteins, including CD9, CD37, CD63, CD81, and CD82. It associates with integrins, MHC class II molecules, and a tyrosine phosphatase and plays a role in cellular activation as part of a signal transduction complex involving other membrane glycoproteins. Defects of CD53 expression on neutrophils appear to be related with recurrent infectious diseases. Cross-linking CD53 using CD53 antibodies led to cytoplasmic calcium fluxes in B cells, monocytes, and granulocytes and activation of the monocyte oxidative burst.
