Monoclonal Antibody to CD59 / Complement Regulatory Protein / Protectin(Clone : SPM616), Clone: [SPM616], Mouse
Biozol Catalog Number:
ABI-36-1954
Supplier Catalog Number:
36-1954
Alternative Catalog Number:
ABI-36-1954-100UG
Manufacturer:
Abeomics
Host:
Mouse
Category:
Antikörper
Application:
FA, FACS, IF, IHC
Species Reactivity:
Human
Immunogen:
Recombinant full-length human CD59 protein
Alternative Names:
CD59||MIC11||MIN1||MIN2||MIN3||MSK21
Reacts with human CD59, a 20kDa glycosyl phosphatidyl-inositol (GPI)-anchored cell surface protein. CD59 regulates complement-mediated cell lysis, and it is involved in lymphocyte signal transduction. This protein is a potent inhibitor of the complement membrane attack complex, whereby it binds complement C8 and/or C9 during the assembly of this complex, thereby inhibiting the incorporation of multiple copies of C9 into the complex, which is necessary for osmolytic pore formation. It inhibits formation of MAC, thus protecting cells from complement-mediated lysis. Genetic defects in GPI-anchor attachment, that cause a reduction or loss of CD59 and CD55 on erythrocytes produce the symptoms of the disease paroxysmal hemoglobinuria (PNH). This MAb is useful for study on GPI-anchored proteins, PNH and CD59 functions. CD59 is widely distributed on cells in all tissues. The expression of CD59 on erythrocytes is important for their survival.
Functional Studies (Order Ab without Azide), Flow Cytometry (1-2ug/million cells), Immunofluorescence (1-2ug/ml), Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT)(Staining of formalin-fixed tissues requires heating tissue sections in
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