Anti-Elastin (ELN) (Marker of Arterial Stiffness and Atherosclerosis) Monoclonal Antibody(Clone: ELN/3131R), Clone: [ELN/3131R], Rabbit
Biozol Catalog Number:
ABI-36-2209
Supplier Catalog Number:
36-2209
Alternative Catalog Number:
ABI-36-2209-100UG
Manufacturer:
Abeomics
Host:
Rabbit
Category:
Antikörper
Application:
IHC
Species Reactivity:
Human
Immunogen:
Recombinant full-length human Elastin protein
Alternative Names:
Elastin, ELN, SVAS, Tropoelastin, WBS, WS
Elastin is a polymeric protein and is the main component of the extracellular matrix of arteries.It is synthesized and secreted as a soluble, single-chain protein (tropoelastin), which undergoes a number of post-translational modifications prior to its organization into an elastic fiber in the extracellular space. Elastin performs a regulatory function during arterial development by controlling proliferation of smooth muscle and stabilizing arterial structure. It imparts elasticityto the connective tissue. During aging, the elasticity of connective tissue is reduced because of the cross-linking of collagenous fibers with elastin. The abnormal accumulation of elastic tissue in blood vessels is found in atherosclerosis and hypertension.
Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 min at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95&degC followed by cooling at RT for 20 minutes),
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