Anti-Blood Group Antigen Lewis B Monoclonal Antibody(Clone: SPM194), Clone: [SPM194], Mouse
Biozol Catalog Number:
ABI-36-2353
Supplier Catalog Number:
36-2353
Alternative Catalog Number:
ABI-36-2353-100UG
Manufacturer:
Abeomics
Host:
Mouse
Category:
Antikörper
Application:
IF, IHC
Species Reactivity:
Human
Immunogen:
Mucin isolated from a human ovarian cyst fluid
Alternative Names:
Blood group Lewis alpha-4-fucosyltransferase, Fucosyltransferase 3, Fucosyltransferase III, FucT-III, FUT3, Galactoside 3(4)-L-fucosyltransferase, gastric mucin, leB, lewis antigen system, lewis B blood group antigen, Lewis FT, major airway glycoprotein
The Lewis histo-blood group system comprises a set of fucosylated glycosphingolipids that are synthesized by exocrine epithelial cells and circulate in body fluids. The glycosphingolipids function in embryogenesis, tissue differentiation, tumor metastasis, inflammation, and bacterial adhesion. They are secondarily absorbed to red blood cells giving rise to their Lewis phenotype. This gene is a member of the fucosyltransferase family, which catalyzes the addition of fucose to precursor polysaccharides in the last step of Lewis antigen biosynthesis. It encodes an enzyme with alpha(1,3)-fucosyltransferase and alpha(1,4)-fucosyltransferase activities. Lewis blood group antigens are carbohydrate moieties structurally integrated in mucous secretions. Lewis antigen system alterations have been described in gastric carcinoma and associated lesions. Anomalous expression of Lewis B antigen has been found in some non-secretory gastric carcinomas and colorectal cancers.
Immunofluorescence (1-2ug/ml), Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95&degC followed by cooling at R
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