Anti-APEX Nuclease I Monoclonal Antibody(Clone: CPTC-APEX1-2), Clone: [CPTC-APEX1-2], Mouse
Biozol Catalog Number:
ABI-36-2504-20
Supplier Catalog Number:
36-2504-20
Alternative Catalog Number:
ABI-36-2504-20-20UG
Manufacturer:
Abeomics
Host:
Mouse
Category:
Antikörper
Application:
FACS, IF, IHC, WB
Species Reactivity:
Human
Immunogen:
Recombinant human full-length APEX1 protein
Alternative Names:
APEX1, AP endonuclease class I, AP lyase, APE, APE-1, APEN, APEX nuclease, Redox factor-1, APX, protein REF-1
APEX / APE1 is a multifunctional protein that plays a central role in the cellular response to oxidative stress. The two major activities of APEX1 in DNA repair and redox regulation of transcriptional factors. Functions as a apurinic/apyrimidinic (AP) endodeoxyribonuclease in the DNA base excision repair (BER) pathway of DNA lesions induced by oxidative and alkylating agents. Patients with genetic variants in APEX1 and XRCC1 have been shown to have a higher risk of lung cancer. Elevated APEX1 levels observed in human testicular cancer may be related to relative resistance to therapy and therefore may serve as a diagnostic marker for refractory disease.
Flow Cytometry (1-2ug/million cells),,Immunofluorescence (1-2ug/ml), Western Blot (1-2ug/ml),,Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 min at RT),(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA
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