Anti-Lymphocyte Specific Protein 1 (LSP1) / pp52 Monoclonal Antibody(Clone: LSP1/3042), Clone: [LSP1/3042], Mouse
Biozol Catalog Number:
ABI-36-2710
Supplier Catalog Number:
36-2710
Alternative Catalog Number:
ABI-36-2710-100UG
Manufacturer:
Abeomics
Host:
Mouse
Category:
Antikörper
Application:
ELISA
Species Reactivity:
Human
Immunogen:
Recombinant fragment of human LSP1 protein (around aa174-278) (exact sequence is proprietary)
Alternative Names:
WP34, pp52, lymphocyte specific protein 1, leukocyte specific protein 1
LSP1 is a hematopoietic-expressed gene that encodes an F-actin-binding, leukocyte-specific (including B and T lymphocytes, granulocytes and macrophages), phosphoprotein. However, mRNA splice variants that do not encode the lympho-specific protein are expressed from this gene in nonlymphoid cell lines as well (myocytes, stromal cells and fibroblasts), sµggesting pp52 has a divergent role in signal transduction. The pp52 (LSP1) locus maps to human chromosome 11p15.5, which is implicated in tumor-related chromosomal translocations found in chronic lymphocytic leukemia. The pp52 promoter contains key elements that control transcriptional activity including an initiator specifying the unique 5 terminus of pp52 mRNA, tandem pairs of Ets and SP1 motifs, and a single C/EBP motif. LSP1 binds the cytoskeleton and has been implicated in affecting cytoskeletal remodeling in a variety of leukocyte functions, including cell motility and chemotaxis.
