Anti-CD45RB (Leucocyte Marker) Monoclonal Antibody(Clone: BRA-11, same as BRA-11G)-CF488, Clone: [BRA-11, same as BRA-11G], Mouse
Biozol Catalog Number:
ABI-36-3072
Supplier Catalog Number:
36-3072
Alternative Catalog Number:
ABI-36-3072-0.5AT100MLATUG/ML
Manufacturer:
Abeomics
Host:
Mouse
Category:
Antikörper
Application:
FACS, IF
Species Reactivity:
Human
Immunogen:
Non-T, non-B CALLA positive ALL cell line REH (Leucocyte Workshop IV and V)
Conjugation:
CF488
Alternative Names:
B220, CD45R, GP180, Leukocyte common antigen (LCA), Loc, Ly-5, Lyt-4, Protein tyrosine phosphatase receptor type C (PTPRC), Receptor-type tyrosine-protein phosphatase C, T200 glycoprotein
CD45R, also designated CD45 and PTPRC, has been identified as a transmembrane glycoprotein, broadly expressed among hematopoietic cells. Multiple isoforms of CD45R are distributed throµghout the immune system according to cell type. These isoforms arise because of alternative splicing of exons 4, 5, and 6. The corresponding protein domains are characterized by the binding of monoclonal antibodies specific for CD45RA (exon 4), CD45RB (exon 5), CD45RC (exon 6) and CD45RO (exons 4 to 6 spliced out). The variation in these isoforms is localized to the extracellular domain of CD45R, while the intracellular domain is conserved. CD45R functions as a phosphor-tyrosine phosphatase. Antibody to CD45 is useful in differential diagnosis of lymphoid tumors from non-hematopoietic undifferentiated neoplasms.
