Anti-Bcl-6 (Follicular Lymphoma Marker) Monoclonal Antibody(Clone: BCL6/1527), Clone: [BCL6/1527], Mouse
Catalog Number:
ABI-36-3109
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| Article Name: | Anti-Bcl-6 (Follicular Lymphoma Marker) Monoclonal Antibody(Clone: BCL6/1527), Clone: [BCL6/1527], Mouse |
| Biozol Catalog Number: | ABI-36-3109 |
| Supplier Catalog Number: | 36-3109 |
| Alternative Catalog Number: | ABI-36-3109-100UG |
| Manufacturer: | Abeomics |
| Host: | Mouse |
| Category: | Antikörper |
| Species Reactivity: | Human |
| Immunogen: | Recombinant human bcl-6 protein fragment (around aa256-389) (Exact sequence is proprietary) |
| Alternative Names: | B-cell lymphoma 5 protein, B-Cell Lymphoma 6 Protein, BCL5, BCL6, BCL6A, cys his2 zinc finger transcription factor, Lymphoma Associated Zinc Finger Gene On Chromosome 3 (LAZ3), Zinc finger and BTB domain-containing protein 27 (ZBTB27), Zinc Finger Protein 51 (ZNF51), zinc finger transcription factor |
| The specificity of this monoclonal antibody to its intended target was validated by HuProtTM Array, containing more than 19,000, full-length human proteins. Recognizes a protein of 95kDa, which is identified as Bcl-6. Antibody to bcl-6 is helpful in a number of diagnostic settings: (1) In the differential diagnosis of small B-cell lymphoma. Follicular lymphoma will show bcl-6 (and CD10) positivity whereas other small B-cell lymphomas are usually negative. (2) Bcl-6 is an important prognostic marker in diffuse large B-cell lymphomas (DLBCL), where CD10, bcl-6 and MUM1/IRF4 are used to identify germinal center and activated B-cell phenotypes. (3) Bcl-6 can be valuable in distinguishing classical Hodgkin lymphoma from nodular lymphocyte predominant Hodgkin lymphoma (NLPHL). The Reed-Sternberg cells of classical Hodgkin lymphoma are bcl-6 negative whereas the large () cells of NLPHL are bcl-6 positive. In contrast, anti-Bcl-6 rarely stains mantle-cell lymphoma and MALT lymphoma. |
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