Biotinylated Cynomolgus CD206 / MMR Protein, His,Avitag(TM) (MALS verified), Human
Biozol Catalog Number:
ABS-CD6-C82E4-25UG
Supplier Catalog Number:
CD6-C82E4-25ug
Alternative Catalog Number:
ABS-CD6-C82E4-25UG
Manufacturer:
AcroBiosystems
Host:
Human
Category:
Proteine/Peptide
Species Reactivity:
Monkey
Conjugation:
Biotin
Mrc1 is a conserved checkpoint mediator protein that transduces the replication stress signal to the downstream effector kinase. Mrc1 and its vertebrate homologue Claspin serve as a mediator for replication stress checkpoint signaling, receiving the signal from Mec1/Rad3/ATR sensor kinase and transmitting it to the effector Rad53/Cds1/Chk1 kinase. The loss of mrc1 checkpoint activity results in the aberrant activation of late/dormant origins in the presence of hydroxyurea. Tumorassociated macrophages (TAMs) expressing the multiligand endocytic receptor mannose receptor (CD206/MRC1) contribute to tumor immunosuppression, angiogenesis, metastasis, and relapse. - Proteine/Peptide
