Cytochrome C (Mitochondrial Marker) Antibody - With BSA and Azide, Clone: [6H2.B4], Mouse, Monoclonal
Catalog Number:
ABT-AH12090-U0100
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| Article Name: | Cytochrome C (Mitochondrial Marker) Antibody - With BSA and Azide, Clone: [6H2.B4], Mouse, Monoclonal |
| Biozol Catalog Number: | ABT-AH12090-U0100 |
| Supplier Catalog Number: | AH12090-U0100 |
| Alternative Catalog Number: | ABT-AH12090-U0100-100UG |
| Manufacturer: | Abcepta |
| Host: | Mouse |
| Category: | Antikörper |
| Application: | FC, IF |
| Species Reactivity: | Human, Mouse, Rat |
| Alternative Names: | Cytochrome c, CYCS, CYC |
| Cytochrome c is a well-characterized mobile electron transport protein that is essential to energy conversion in all aerobic organisms. In mammalian cells, this highly conserved protein is normally localized to the mitochondrial inter-membrane space. More recent studies have identified cytosolic cytochrome c as a factor necessary for activation of apoptosis. During apoptosis, cytochrome c is trans-located from the mitochondrial membrane to the cytosol, where it is required for activation of caspase-3 (CPP32). Overexpression of Bcl-2 has been shown to prevent the translocation of cytochrome c, thereby blocking the apoptotic process. Overexpression of Bax has been shown to induce the release of cytochrome c and to induce cell death. The release of cytochrome c from the mitochondria is thought to trigger an apoptotic cascade, whereby Apaf-1 binds to Apaf-3 (caspase-9) in a cytochrome c-dependent manner, leading to caspase-9 cleavage of caspase-3. |
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