Beta-2 Microglobulin (Renal Failure & Tumor Marker) Antibody - With BSA and Azide, Clone: [BBM.1], Mouse, Monoclonal
Catalog Number:
ABT-AH12133-U0100
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| Article Name: | Beta-2 Microglobulin (Renal Failure & Tumor Marker) Antibody - With BSA and Azide, Clone: [BBM.1], Mouse, Monoclonal |
| Biozol Catalog Number: | ABT-AH12133-U0100 |
| Supplier Catalog Number: | AH12133-U0100 |
| Alternative Catalog Number: | ABT-AH12133-U0100-100UG |
| Manufacturer: | Abcepta |
| Host: | Mouse |
| Category: | Antikörper |
| Application: | FC, IF, IHC-Fr |
| Species Reactivity: | Human |
| Alternative Names: | Beta-2-microglobulin, Beta-2-microglobulin form pI 5.3, B2M |
| Recognizes a protein of 12kDa, identified as microglobulin. Major histocompatibility complex (MHC) class 1 molecules bind to antigens for presentation on the surface of cells. The proteasome is responsible for producing these antigens from the components of foreign pathogens. MHC class 1 molecules consist of an alpha heavy chain that contains three subdomains (alpha1, alpha2, alpha3) and a non-covalent associating light chain, known as beta-2-Microglobulin. beta-2-Microglobulin associates with the alpha3 subdomain of the alpha heavy chain and forms an immunoglobulin domain-like structure that mediates proper folding and expression of MHC class 1 molecules. The alpha1 and alpha2 domains of the alpha heavy chain form the peptide antigen-binding cleft. Mutations in the beta-2-Microglobulin gene can enhance the progression of malignant melanoma phenotypes. |
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