CD8B (Cytotoxic / Suppressor T-Cell Marker) Antibody - With BSA and Azide, Clone: [BU88], Mouse, Monoclonal
Catalog Number:
ABT-AH12641-U0100
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| Article Name: | CD8B (Cytotoxic / Suppressor T-Cell Marker) Antibody - With BSA and Azide, Clone: [BU88], Mouse, Monoclonal |
| Biozol Catalog Number: | ABT-AH12641-U0100 |
| Supplier Catalog Number: | AH12641-U0100 |
| Alternative Catalog Number: | ABT-AH12641-U0100-100UG |
| Manufacturer: | Abcepta |
| Host: | Mouse |
| Category: | Antikörper |
| Application: | FC, IF |
| Species Reactivity: | Human |
| Alternative Names: | T-cell surface glycoprotein CD8 beta chain, CD8b, CD8B, CD8B1 |
| The T cell receptor (TCR) is a heterodimer composed of either Ī and Ī or Ī and Ī chains. CD3 chains and the CD4 or CD8 co-receptors are also required for efficient signal transduction through the TCR. The TCR is expressed on T helper and T cytotoxic cells that can be distinguished by their expression of CD4 and CD8. T helper cells express CD4 proteins and T cytotoxic cells display CD8. CD8 (also designated Leu 2 or T8), a cell surface glycoprotein, is a two chain complex (Ī -Ī or Ī -Ī ) receptor that binds class I MHC molecules presented by the antigen-presenting cell (APC). A primary function of CD8 is to facilitate antigen recognition by the TCR and to strengthen the avidity of the TCR-antigen interactions. An additional role for CD8-expressing T cells may be to maintain low levels of HIV expression. |
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