CD19 (B-Lymphocyte Marker) Antibody - With BSA and Azide, Clone: [C19/366], Mouse, Monoclonal
Catalog Number:
ABT-AH12651-U0100
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| Article Name: | CD19 (B-Lymphocyte Marker) Antibody - With BSA and Azide, Clone: [C19/366], Mouse, Monoclonal |
| Biozol Catalog Number: | ABT-AH12651-U0100 |
| Supplier Catalog Number: | AH12651-U0100 |
| Alternative Catalog Number: | ABT-AH12651-U0100-100UG |
| Manufacturer: | Abcepta |
| Host: | Mouse |
| Category: | Antikörper |
| Application: | FC, IF |
| Species Reactivity: | Human |
| Alternative Names: | B-lymphocyte antigen CD19, B-lymphocyte surface antigen B4, Differentiation antigen CD19, T-cell surface antigen Leu-12, CD19, CD19 |
| CD19 is a transmembrane glycoprotein that contains two extracellular immunoglobulin-like domains. CD19 is present in both benign and malignant B-cells and is considered to be the most reliable surface marker of this lineage over a wide range of maturational stages. In normal lymphoid tissue, CD19 is observed in germinal centers, in mantle zone cells, and in scattered cells of the inter-follicular areas. Anti-CD19 exhibits an overall immunoreactivity pattern similar to those of the antibodies against CD20 and CD22. However, in contrast to CD20, expression of CD19 is continuous throughout B-cell development and through terminal differentiation of B-cells into plasma cells. Anti-CD19 positivity is seen in the vast majority of B-cell neoplasms commonly at a lower intensity than normal B-cell counterparts. Plasma cell neoplasms are nearly always negative, as are T-cell neoplasms. |
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