CD37 (Peripheral Mature B-Cell Marker) Antibody - With BSA and Azide, Clone: [IPO-24], Mouse, Monoclonal
Catalog Number:
ABT-AH12730-U0100
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| Article Name: | CD37 (Peripheral Mature B-Cell Marker) Antibody - With BSA and Azide, Clone: [IPO-24], Mouse, Monoclonal |
| Biozol Catalog Number: | ABT-AH12730-U0100 |
| Supplier Catalog Number: | AH12730-U0100 |
| Alternative Catalog Number: | ABT-AH12730-U0100-100UG |
| Manufacturer: | Abcepta |
| Host: | Mouse |
| Category: | Antikörper |
| Application: | FC, IF |
| Species Reactivity: | Human |
| Alternative Names: | Leukocyte antigen CD37, Tetraspanin-26, Tspan-26, CD37, CD37, TSPAN26 |
| Recognizes a protein of 33-55kDa, identified as CD37 (Workshop V, Code CD37.7). CD37 is strongly expressed on normal and neoplastic mature (sIg+) B-lymphocytes. In B-cell ontogeny, CD37 appears after the pre-B-cell stage, is maintained during peripheral B-cell development and is lost upon terminal differentiation into plasma cells.1 CD37 is also present, at low densities, on resting and activated T cells, neutrophils, monocytes, and some myelomonocytic leukemia cells. It is absent from platelets, erythrocytes. CD37 is a member of a family of tetraspan transmembrane proteins, including CD9, CD53, CD63, CD81, and CD82. It associates other tetraspan transmembrane proteins and MHC class II molecules to form a large complex at the surface of B cells and play a role in signal transduction. CD37 is a valuable and stable marker for peripheral mature B-cells and corresponding malignancies like B-cell chronic lymphocytic leukemia (B-CLL), hairy cell leukemia (HCL), and all types of B-cell non-Hodgkinā€(TM) lymphoma (B-NHL). |
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