CD53 (TSPAN25) Antibody - With BSA and Azide, Clone: [63-5A3], Mouse, Monoclonal
Catalog Number:
ABT-AH12760-U0100
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| Article Name: | CD53 (TSPAN25) Antibody - With BSA and Azide, Clone: [63-5A3], Mouse, Monoclonal |
| Biozol Catalog Number: | ABT-AH12760-U0100 |
| Supplier Catalog Number: | AH12760-U0100 |
| Alternative Catalog Number: | ABT-AH12760-U0100-100UG |
| Manufacturer: | Abcepta |
| Host: | Mouse |
| Category: | Antikörper |
| Application: | FC, IF |
| Species Reactivity: | Human |
| Alternative Names: | Leukocyte surface antigen CD53, Cell surface glycoprotein CD53, Tetraspanin-25, Tspan-25, CD53, CD53, MOX44, TSPAN25 |
| Recognizes a protein of 33-55kDa, identified as CD53 (Workshop V, Code CD53.1). CD53 is expressed on monocytes, and macrophages, granulocytes, dendritic cells, osteoblasts and osteoclasts, NK cells, and on T- and B-cells from every stage of differentiation but is absent from platelets, erythrocytes, and non-haemopoietic cells. CD53 is a member of a family of tetraspan transmembrane proteins, including CD9, CD37, CD63, CD81, and CD82. It associates with integrins, MHC class II molecules, and a tyrosine phosphatase and plays a role in cellular activation as part of a signal transduction complex involving other membrane glycoproteins. Defects of CD53 expression on neutrophils appear to be related with recurrent infectious diseases. Cross-linking CD53 using CD53 antibodies led to cytoplasmic calcium fluxes in B cells, monocytes, and granulocytes and activation of the monocyte oxidative burst. |
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