Major Vault Protein (MVP) Antibody - With BSA and Azide, Clone: [1014], Mouse, Monoclonal
Catalog Number:
ABT-AH12831-U0020
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| Article Name: | Major Vault Protein (MVP) Antibody - With BSA and Azide, Clone: [1014], Mouse, Monoclonal |
| Biozol Catalog Number: | ABT-AH12831-U0020 |
| Supplier Catalog Number: | AH12831-U0020 |
| Alternative Catalog Number: | ABT-AH12831-U0020-20UG |
| Manufacturer: | Abcepta |
| Host: | Mouse |
| Category: | Antikörper |
| Application: | FC, IF |
| Species Reactivity: | Human |
| Alternative Names: | Major vault protein, MVP, Lung resistance-related protein, MVP, LRP |
| Recognizes a protein of 104kDa-110kDa, characterized as major vault protein (MVP). Vaults are large ribonucleoprotein particles (RNPs) present in all eukaryotic cells. They have a complex morphology, including several small molecules of RNA, but a single protein species. The MVP accounts for >70% of their mass. Their shape is reminiscent of the nucleopore central plug. Treatment of cells with estradiol increases the amount of MVP in nuclear extract. The hormone-dependent interaction of vaults with ER is prevented in vitro by sodium molybdate. Antibodies to estrogen, progesterone and glucocorticoid receptors are able to co-immunoprecipitate the MVP. MVP is overexpressed in many neoplastic tissues and cell lines. Expression of MVP predicts a poor response to chemotherapy. |
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