Anti-CD257 / BAFF / TNFSF13B Antibody, Clone: [C257/1638], Mouse, Monoclonal
Catalog Number:
ABT-AH13091-U0100
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| Article Name: | Anti-CD257 / BAFF / TNFSF13B Antibody, Clone: [C257/1638], Mouse, Monoclonal |
| Biozol Catalog Number: | ABT-AH13091-U0100 |
| Supplier Catalog Number: | AH13091-U0100 |
| Alternative Catalog Number: | ABT-AH13091-U0100-100UG |
| Manufacturer: | Abcepta |
| Host: | Mouse |
| Category: | Antikörper |
| Application: | FC, IF |
| Species Reactivity: | Human |
| Alternative Names: | ApoL related ligand TALL 1, B lymphocyte stimulator, B-cell-activating factor, BAFF, BLyS, CD257, Dendritic cell-derived TNF-like molecule, DTL, PRO738, TALL-1, THANK, TNFSF13B, TNFSF20, Tumor necrosis factor ligand superfamily member 13b, Tumor necrosis factor ligand superfamily member 20, ZTNF4 |
| BAFF/CD257 is a type II transmembrane protein, and a member of the tumor necrosis factor ligand superfamily. It is proteolytically cleaved to form a soluble protein. BAFF, like other TNF ligand family members, forms homo-trimers. The predicted molecular weight of a BAFF monomer is approximately 31kDa. It is expressed on peripheral blood B and T lymphocytes, monocytes, macrophages, and dendritic cells and is upregulated by IFN-gamma and down-regulated by PMA/ionomycin treatment. BAFF stimulates B and T cell immunity and regulates humoral immunity by binding TACI and BCMA receptors, BAFF prevents apoptosis and promotes B cell survival by binding the BAFF-specific receptor (BAFFR/BR3). |
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