Anti-DOG-1 / TMEM16A Antibody, Clone: [DG1/1487R], Rabbit, Monoclonal
Catalog Number:
ABT-AH13456-U0100
- Images (0)
| Article Name: | Anti-DOG-1 / TMEM16A Antibody, Clone: [DG1/1487R], Rabbit, Monoclonal |
| Biozol Catalog Number: | ABT-AH13456-U0100 |
| Supplier Catalog Number: | AH13456-U0100 |
| Alternative Catalog Number: | ABT-AH13456-U0100-100UG |
| Manufacturer: | Abcepta |
| Host: | Rabbit |
| Category: | Antikörper |
| Application: | FC, IF, IHC-P |
| Species Reactivity: | Human |
| Alternative Names: | Anoctamin 1, Calcium Activated Chloride Channel, Discovered On Gastrointestinal Stromal Tumors Protein 1, TAOS2, ORAOV2, TMEM16A |
| Expression of DOG-1 protein is elevated in the gastrointestinal stromal tumors (GIST s), c-kit signaling-driven mesenchymal tumors of the GI tract. DOG-1 is rarely expressed in other soft tissue tumors, which, due to appearance, may be difficult to diagnose. Immunoreactivity for DOG-1 has been reported in 97.8 percent of scorable GIST s, including all c-kit negative GIST s. Overexpression of DOG-1 has been suggested to aid in the identification of GISTs, including Platelet-Derived Growth Factor Receptor Alpha mutants that fail to express c-kit antigen. The overall sensitivity of DOG1 and c-kit in GIST s is nearly identical: 94.4% vs. 94.7%. |
Product Guarantee and Expert Support
