Major vault protein, MVP, Lung resistance-related protein, MVP, LRP
MVP, the major vault protein, is a lung resistance-related protein. Vaults are multi-subunit structures that may be involved in nucleo-cytoplasmic transport. This protein mediates drug resistance, perhaps via a transport process. It is widely distributed in normal tissues, and overexpressed in multidrug-resistant cancer cells. The protein overexpression is a potentially useful marker of clinical drug resistance.
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Target:
This MVP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 863-893 amino acids from the C-terminal region of human MVP.
Antibody Type:
Polyclonal Antibody
The anti-MVP C-term Antibody (Cat.AP6216a) is used in Western blot to detect MVP in A375 lysate.
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