MAP3K8 Antibody - C-terminal region
Catalog Number:
ASB-ARP30649_T100
- Images (3)
| Article Name: | MAP3K8 Antibody - C-terminal region |
| Biozol Catalog Number: | ASB-ARP30649_T100 |
| Supplier Catalog Number: | ARP30649_T100 |
| Alternative Catalog Number: | ASB-ARP30649_T100-25UL,ASB-ARP30649_T100-100UL |
| Manufacturer: | Aviva |
| Host: | Rabbit |
| Category: | Proteine/Peptide |
| Application: | WB |
| Species Reactivity: | Bovine, Canine, Equine, Guinea pig, Human, Mouse, Rabbit, Rat |
| Immunogen: | The immunogen is a synthetic peptide directed towards the C terminal region of human MAP3K8 |
| Alternative Names: | COT, EST, ESTF, TPL2, AURA2, MEKK8, Tpl-2, c-COT |
| MAP3K8 is a member of the serine/threonine protein kinase family. This kinase can activate both the MAP kinase and JNK kinase pathways. This kinase was shown to activate IkappaB kinases, and thus induce the nuclear production of NF-kappaB. This kinase was also found to promote the production of TNF-alpha and IL-2 during T lymphocyte activation. Studies of a similar gene in rat suggested the direct involvement of this kinase in the proteolysis of NF-kappaB1,p105 (NFKB1). This gene may also utilize a downstream in-frame translation start codon, and thus produce an isoform containing a shorter N-terminus. The shorter isoform has been shown to display weaker transforming activity. |
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WB Suggested Anti-MAP3K8 Antibody Titration: 2.5ug/ml ELISA Titer: 1:1562500 Positive Control: Jurkat cell lysate |
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25 ug of the indicated Human whole cell extracts was loaded onto a 12% SDS-PAGE gel. 1 ug/mL of the antibody was used in this experiment. The protein may be modified by phosphorylation. |
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MAP3K8 antibody - C-terminal region (ARP30649_T100) in Human Jurkat using Western Blot |
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