Bovine, Equine, Human, Mouse, Porcine, Rabbit, Rat, Sheep
Immunogen:
The immunogen is a synthetic peptide directed towards the N terminal region of human NR3C1
Alternative Names:
GR, GCR, GRL, GCCR, GCRST
NR3C1 is a receptor for glucocorticoids that can act as both a transcription factor and as a regulator of other transcription factors. This protein can also be found in heteromeric cytoplasmic complexes along with heat shock factors and immunophilins. The protein is typically found in the cytoplasm until it binds a ligand, which induces transport into the nucleus. Mutations in this gene are a cause of glucocorticoid resistance, or cortisol, resistance.