ING3 Antibody - middle region
Catalog Number:
ASB-ARP33347_P050
- Images (3)
| Article Name: | ING3 Antibody - middle region |
| Biozol Catalog Number: | ASB-ARP33347_P050 |
| Supplier Catalog Number: | ARP33347_P050 |
| Alternative Catalog Number: | ASB-ARP33347_P050-25UL,ASB-ARP33347_P050-100UL |
| Manufacturer: | Aviva |
| Host: | Rabbit |
| Category: | Proteine/Peptide |
| Application: | IHC, WB |
| Species Reactivity: | Bovine, Canine, Equine, Guinea pig, Human, Mouse, Rabbit, Rat, Yeast, Zebrafish |
| Immunogen: | The immunogen is a synthetic peptide directed towards the middle region of human ING3 |
| Alternative Names: | Eaf4, ING2, MEAF4, p47ING3 |
| ING3 is similar to ING1, a tumor suppressor protein that can interact with TP53, inhibit cell growth, and induce apoptosis. This protein contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. This gene can activate p53 trans-activated promoters, including promoters of p21/waf1 and bax. Overexpression of this gene has been shown to inhibit cell growth and induce apoptosis. Allelic loss and reduced expression of this gene were detected in head and neck cancers.The protein encoded by this gene is similar to ING1, a tumor suppressor protein that can interact with TP53, inhibit cell growth, and induce apoptosis. This protein contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. This gene can activate p53 trans-activated promoters, including promoters of p21/waf1 and bax. Overexpression of this gene has been shown to inhibit cell growth and induce apoptosis. Allelic loss and reduced expression of this gene were detected in head and neck cancers. Two alternatively spliced transcript variants encoding different isoforms have been observed. |
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Immunohistochemistry with Placenta tissue at an antibody concentration of 5ug/ml using anti-ING3 antibody (ARP33347_P050) |
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WB Suggested Anti-ING3 Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1:312500 Positive Control: Human heart |
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ING3 antibody - middle region (ARP33347_P050) in Human heart using Western Blot |
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