Pthlh Antibody - middle region
Catalog Number:
ASB-ARP33886_P050
- Images (3)
| Article Name: | Pthlh Antibody - middle region |
| Biozol Catalog Number: | ASB-ARP33886_P050 |
| Supplier Catalog Number: | ARP33886_P050 |
| Alternative Catalog Number: | ASB-ARP33886_P050-25UL,ASB-ARP33886_P050-100UL |
| Manufacturer: | Aviva |
| Host: | Rabbit |
| Category: | Proteine/Peptide |
| Application: | IHC, WB |
| Species Reactivity: | Bovine, Canine, Equine, Goat, Guinea pig, Human, Mouse, Rabbit, Rat, Sheep |
| Immunogen: | The immunogen is a synthetic peptide corresponding to a region of Mouse |
| Alternative Names: | Pt, PLP, PTH-l, Pthrp, PTH-like |
| Pthlh is a neuroendocrine peptide which is a critical regulator of cellular and organ growth, development, migration, differentiation and survival and of epithelial calcium ion transport. It regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth. It is required for skeletal homeostasis. It promotes mammary mesenchyme differentiation and bud outgrowth by modulating mesenchymal cell responsiveness to BMPs. It upregulates BMPR1A expression in the mammary mesenchyme and this increases the sensitivity of these cells to BMPs and allows them to respond to BMP4 in a paracrine and/or autocrine fashion. BMP4 signaling in the mesenchyme, in turn, triggers epithelial outgrowth and augments MSX2 expression, which causes the mammary mesenchyme to inhibit hair follicle formation within the nipple sheath. |
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Immunohistochemistry with Lung tissue at an antibody concentration of 5ug/ml using anti-Pthlh antibody (ARP33886_P050) |
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WB Suggested Anti-Pthlh Antibody Titration: 1 ug/ml Positive Control: Mouse Brain lysate |
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Pthlh antibody - middle region (ARP33886_P050) in Mouse Brain using Western Blot |
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