TRPV4 Antibody - middle region
Catalog Number:
ASB-ARP35330_P050
- Images (3)
| Article Name: | TRPV4 Antibody - middle region |
| Biozol Catalog Number: | ASB-ARP35330_P050 |
| Supplier Catalog Number: | ARP35330_P050 |
| Alternative Catalog Number: | ASB-ARP35330_P050-25UL,ASB-ARP35330_P050-100UL |
| Manufacturer: | Aviva |
| Host: | Rabbit |
| Category: | Proteine/Peptide |
| Application: | IHC, WB |
| Species Reactivity: | Bovine, Canine, Guinea pig, Human, Mouse, Porcine, Rabbit, Rat |
| Immunogen: | The immunogen is a synthetic peptide directed towards the middle region of human TRPV4 |
| Alternative Names: | SMAL, VRL2, BCYM3, CMT2C, SPSMA, TRP12, VROAC, HMSN2C, OTRPC4, SSQTL1 |
| TRPV4 is a non-selective calcium permeant cation channel probably involved in osmotic sensitivity and mechanosensitivity. Activation of TRPV4 by exposure to hypotonicity within the physiological range exhibits an outward rectification. TRPV4 also activated by low pH, citrate and phorbol esters and increase of intracellular Ca2+ potentiates currents. Channel activity seems to be regulated by a calmodulin-dependent mechanism with a negative feedback mechanism.Defects in TRPV4 are the cause of brachyolmia type 3 (BRAC3) This gene encodes a member of the OSM9-like transient receptor potential channel (OTRPC) subfamily in the transient receptor potential (TRP) superfamily of ion channels. The encoded protein is a Ca2+-permeable, nonselective cation channel that is thought to be involved in the regulation of systemic osmotic pressure. Two transcript variants encoding different isoforms have been found for this gene. |
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TRPV4 Rat HippocampusWe tested the antibodies in Immunohistochemistry studies. The dilutions for all the above primary antibodies were 1:500 and the same for the secondary antibody, Alexa Fluor 568-conjugated goat anti-rabbit antibodies (Invitrogen). |
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WB Suggested Anti-TRPV4 Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1:12500 Positive Control: ACHN cell lysate |
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TRPV4 antibody - middle region (ARP35330_P050) in Human ACHN using Western Blot |
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