XBP1 Antibody - C-terminal region
Catalog Number:
ASB-ARP38553_P050
- Images (3)
| Article Name: | XBP1 Antibody - C-terminal region |
| Biozol Catalog Number: | ASB-ARP38553_P050 |
| Supplier Catalog Number: | ARP38553_P050 |
| Alternative Catalog Number: | ASB-ARP38553_P050-25UL,ASB-ARP38553_P050-100UL |
| Manufacturer: | Aviva |
| Host: | Rabbit |
| Category: | Proteine/Peptide |
| Application: | WB |
| Species Reactivity: | Bovine, Equine, Human, Mouse, Porcine, Rabbit, Rat |
| Immunogen: | The immunogen is a synthetic peptide directed towards the C terminal region of human XBP1 |
| Alternative Names: | XBP2, TREB5, XBP-1, TREB-5 |
| XBP1 is a transcription factor that regulates MHC class II genes by binding to a promoter element referred to as an X box. XBP1 is a bZIP protein, which was also identified as a cellular transcription factor that binds to an enhancer in the promoter of the T cell leukemia virus type 1 promoter. It may increase expression of viral proteins by acting as the DNA binding partner of a viral transactivator.This gene encodes a transcription factor that regulates MHC class II genes by binding to a promoter element referred to as an X box. This gene product is a bZIP protein, which was also identified as a cellular transcription factor that binds to an enhancer in the promoter of the T cell leukemia virus type 1 promoter. It may increase expression of viral proteins by acting as the DNA binding partner of a viral transactivator. It has been found that upon accumulation of unfolded proteins in the endoplasmic reticulum (ER), the mRNA of this gene is processed to an active form by an unconventional splicing mechanism that is mediated by the endonuclease inositol-requiring enzyme 1 (IRE1). The resulting loss of 26 nt from the spliced mRNA causes a frame-shift and an isoform XBP1(S), which is the functionally active transcription factor. The isoform encoded by the unspliced mRNA, XBP1(U), is constitutively expressed, and thought to function as a negative feedback regulator of XBP1(S), which shuts off transcription of target genes during the recovery phase of ER stress. A pseudogene of XBP1 has been identified and localized to chromosome 5. |
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WB Suggested Anti-XBP1 Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1:1562500 Positive Control: Jurkat cell lysate |
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Lanes: Lane 1: 40ug whole canine retina Primary Antibody Dilution: 1:1000 Secondary Antibody: Anti-rabbit-HRP Secondary Antibody Dilution: 1:5000 Gene Name: XBP1 a Submitted by: Dr. Stefania Marsili and Dr. William Beltran, University of Pennsylvania |
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XBP1 antibody - C-terminal region (ARP38553_P050) in Human Jurkat using Western Blot |
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