Dpf3 Antibody - N-terminal region
Catalog Number:
ASB-ARP38943_P050
- Images (3)
| Article Name: | Dpf3 Antibody - N-terminal region |
| Biozol Catalog Number: | ASB-ARP38943_P050 |
| Supplier Catalog Number: | ARP38943_P050 |
| Alternative Catalog Number: | ASB-ARP38943_P050-25UL,ASB-ARP38943_P050-100UL |
| Manufacturer: | Aviva |
| Host: | Rabbit |
| Category: | Proteine/Peptide |
| Application: | IHC, WB |
| Species Reactivity: | Equine, Guinea pig, Human, Mouse, Rabbit, Rat, Zebrafish |
| Alternative Names: | CERD, CERD4, cer-d, BAF45C, C78788, cer-d4, Gm18872, 2810403B03Rik, 6530402L11Rik |
| Dpf3 is a muscle-specific component of the BAF complex, a multiprotein complex involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Dpf3 specifically binds acetylated lysines on histone 3 and 4 (H3K14ac, H3K9ac, H4K5ac, H4K8ac, H4K12ac, H4K16ac). In the complex, it acts as a tissue-specific anchor between histone acetylations and methylations and chromatin remodeling. It thereby probably plays an essential role in heart and skeletal muscle development. Belongs to the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. |
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Rabbit Anti-Dpf3 Antibody Catalog Number: ARP38943_P050 Formalin Fixed Paraffin Embedded Tissue: Human Adult heart Observed Staining: Nuclear (not in cardiomyocytes but in fibrocytes in endomysium Primary Antibody Concentration: 1:600 Secondary Antibody: Donkey anti-Rabbit-Cy2/3 Secondary Antibody Concentration: 1:200 Magnification: 20X Exposure Time: 0.5 a€'' 2.0 sec Protocol located in Reviews and Data. |
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WB Suggested Anti-Dpf3 Antibody Titration: 1.0 ug/ml Positive Control: Mouse Spleen |
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Dpf3 antibody - N-terminal region (ARP38943_P050) in Mouse Spleen using Western Blot |
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