PCBP1 Antibody - middle region

Article Name:	PCBP1 Antibody - middle region
Biozol Catalog Number:	ASB-ARP40630_T100
Supplier Catalog Number:	ARP40630_T100
Alternative Catalog Number:	ASB-ARP40630_T100-25UL,ASB-ARP40630_T100-100UL
Manufacturer:	Aviva
Host:	Rabbit
Category:	Proteine/Peptide
Application:	WB
Species Reactivity:	Bovine, Canine, Equine, Guinea pig, Human, Mouse, Rabbit, Rat
Immunogen:	The immunogen is a synthetic peptide directed towards the middle region of human PCBP1
Alternative Names:	HNRPX, HNRPE1, hnRNP-X, HEL-S-85, hnRNP-E1

PCBP1 appears to be multifunctional. It along with PCBP-2 and hnRNPK corresponds to the major cellular poly(rC)-binding protein. It contains three K-homologous (KH) domains which may be involved in RNA binding. This protein together with PCBP-2 also functions as translational coactivators of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES and promote poliovirus RNA replication by binding to its 5-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human Papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. PCBP1 is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability.This intronless gene is thought to be generated by retrotransposition of a fully processed PCBP-2 mRNA. This gene and PCBP-2 has paralogues PCBP3 and PCBP4 which is thought to arose as a result of duplication events of entire genes. The protein encoded by this gene appears to be multifunctional. It along with PCBP-2 and hnRNPK corresponds to the major cellular poly(rC)-binding proteins. It contains three K-homologous (KH) domains which may be involved in RNA binding. This encoded protein together with PCBP-2 also functions as translational coactivators of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES and promote poliovirus RNA replication by binding to its 5-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human Papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. The encoded protein is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability.

Clonality:	Polyclonal
Concentration:	1.0 mg/ml
Molecular Weight:	39kDa
NCBI:	5093
UniProt:	Q15365
Form:	Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

	WB Suggested Anti-PCBP1 Antibody Titration: 1.25ug/ml Positive Control: HepG2 cell lysatePCBP1 is supported by BioGPS gene expression data to be expressed in HepG2
	Host: Rabbit Target Name: PCBP1 Sample Type: HepG2 Lane A: Primary Antibody Lane B: Primary Antibody + Blocking Peptide Primary Antibody Concentration: 2.5ug/mL Peptide Concentration: 2.0ug/mL Lysate Quantity: 25ug/lane Gel Concentration: 12%PCBP1 is supported by BioGPS gene expression data to be expressed in HepG2
	Host: Mouse Target Name: PCBP1 Sample Tissue: Mouse Brain Antibody Dilution: 1ug/ml
	PCBP1 antibody - middle region (ARP40630_T100) in Human HepG2 using Western Blot