NXF1 Antibody - N-terminal region
Catalog Number:
ASB-ARP40639_T100
- Images (4)
| Article Name: | NXF1 Antibody - N-terminal region |
| Biozol Catalog Number: | ASB-ARP40639_T100 |
| Supplier Catalog Number: | ARP40639_T100 |
| Alternative Catalog Number: | ASB-ARP40639_T100-25UL,ASB-ARP40639_T100-100UL |
| Manufacturer: | Aviva |
| Host: | Rabbit |
| Category: | Proteine/Peptide |
| Application: | IHC, WB |
| Species Reactivity: | Bovine, Canine, Guinea pig, Human, Mouse, Rat |
| Immunogen: | The immunogen is a synthetic peptide directed towards the N terminal region of human NXF1 |
| Alternative Names: | TAP, MEX67 |
| NXF1 is one member of a family of nuclear RNA export factor. Common domain features of this family are a noncanonical RNP-type RNA-binding domain (RBD), 4 leucine-rich repeats (LRRs), a nuclear transport factor 2 (NTF2)-like domain that allows heterodimerization with NTF2-related export protein-1 (NXT1), and a ubiquitin-associated domain that mediates interactions with nucleoporins. The LRRs and NTF2-like domains are required for export activity. NXF1 shuttles between the nucleus and the cytoplasm and binds in vivo to poly(A)+ RNA. NXF1 overcomes the mRNA export block caused by the presence of saturating amounts of CTE (constitutive transport element) RNA of type D retroviruses.This gene is one member of a family of nuclear RNA export factor genes. Common domain features of this family are a noncanonical RNP-type RNA-binding domain (RBD), 4 leucine-rich repeats (LRRs), a nuclear transport factor 2 (NTF2)-like domain that allows heterodimerization with NTF2-related export protein-1 (NXT1), and a ubiquitin-associated domain that mediates interactions with nucleoporins. The LRRs and NTF2-like domains are required for export activity. Alternative splicing seems to be a common mechanism in this gene family. The encoded protein of this gene shuttles between the nucleus and the cytoplasm and binds in vivo to poly(A)+ RNA. It is the vertebrate homologue of the yeast protein Mex67p. The encoded protein overcomes the mRNA export block caused by the presence of saturating amounts of CTE (constitutive transport element) RNA of type D retroviruses. |
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Rabbit Anti-NXF1Antibody Catalog Number: ARP40639 Paraffin Embedded Tissue: Human Kidney Cellular Data: Epithelial cells of renal tubule Antibody Concentration: 4.0-8.0 ug/ml Magnification: 400X |
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WB Suggested Anti-NXF1 Antibody Titration: 1.25ug/ml Positive Control: HepG2 cell lysateNXF1 is supported by BioGPS gene expression data to be expressed in HepG2 |
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Lanes: Lane 1: 7ug HeLa lysate+EGFP SiRNA Lane 2: 7ug HeLa lysate+NXF1 SiRNA Primary Antibody Dilution: 1:300 Secondary Antibody: Anti-rabbit-HRP Secondary Antibody Dilution: 1:500 Gene Name: NXF1 Submitted by: Seiji Masuda, Kitashirakawa Oiwakecho, Kyoto University NXF1 is supported by BioGPS gene expression data to be expressed in HeLa |
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NXF1 antibody - N-terminal region (ARP40639_T100) in Human HepG2 using Western Blot |
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