NR1I3 Antibody - middle region
Catalog Number:
ASB-ARP45624_P050
- Images (3)
| Article Name: | NR1I3 Antibody - middle region |
| Biozol Catalog Number: | ASB-ARP45624_P050 |
| Supplier Catalog Number: | ARP45624_P050 |
| Alternative Catalog Number: | ASB-ARP45624_P050-25UL,ASB-ARP45624_P050-100UL |
| Manufacturer: | Aviva |
| Host: | Rabbit |
| Category: | Proteine/Peptide |
| Application: | IHC, WB |
| Species Reactivity: | Bovine, Canine, Equine, Guinea pig, Human, Mouse, Porcine, Rabbit, Rat, Zebrafish |
| Immunogen: | The immunogen is a synthetic peptide directed towards the middle region of human NR1I3 |
| Alternative Names: | CAR, CAR1, MB67 |
| NR1I3 mediates the induction of transcription of cytochrome P450 (CYP) genes by phenobarbital (PB) and PB-type inducers. NR1I3 activation induces hepatic expression of detoxification enzymes and transporters and increases liver size. NR1I3 can also regulate both liver homeostasis and tumorigenesis in response to xenobiotic stresses. This gene encodes a member of the nuclear receptor superfamily, and is a key regulator of xenobiotic and endobiotic metabolism. The protein binds to DNA as a monomer or a heterodimer with the retinoid X receptor and regulates the transcription of target genes involved in drug metabolism and bilirubin clearance, such as cytochrome P450 family members. Unlike most nuclear receptors, this transcriptional regulator is constitutively active in the absence of ligand but is regulated by both agonists and inverse agonists. Ligand binding results in translocation of this protein to the nucleus, where it activates or represses target gene transcription. These ligands include bilirubin, a variety of foreign compounds, steroid hormones, and prescription drugs. Multiple transcript variants encoding different isoforms have been found for this gene. |
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Immunohistochemistry with Human Colon lysate tissue at an antibody concentration of 5.0ug/ml using anti-NR1I3 antibody (ARP45624_P050) |
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WB Suggested Anti-NR1I3 Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1:312500 Positive Control: Jurkat cell lysate |
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NR1I3 antibody - middle region (ARP45624_P050) in Human Jurkat using Western Blot |
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