SELENON Antibody - C-terminal region
Catalog Number:
ASB-ARP47655_P050
- Images (3)
| Article Name: | SELENON Antibody - C-terminal region |
| Biozol Catalog Number: | ASB-ARP47655_P050 |
| Supplier Catalog Number: | ARP47655_P050 |
| Alternative Catalog Number: | ASB-ARP47655_P050-25UL,ASB-ARP47655_P050-100UL |
| Manufacturer: | Aviva |
| Host: | Rabbit |
| Category: | Proteine/Peptide |
| Application: | IHC, WB |
| Species Reactivity: | Bovine, Equine, Guinea pig, Human, Mouse, Rat, Zebrafish |
| Immunogen: | The immunogen is a synthetic peptide directed towards the C terminal region of human SEPN1 |
| Alternative Names: | RSS, CFTD, SELN, MDRS1, RSMD1, SEPN1 |
| This gene encodes a glycoprotein that is localized in the endoplasmic reticulum. It plays an important role in cell protection against oxidative stress, and in the regulation of redox-related calcium homeostasis. Mutations in this gene are associated with early onset muscle disorders, referred to as SEPN1-related myopathy. SEPN1-related myopathy consists of 4 autosomal recessive disorders, originally thought to be separate entities: rigid spine muscular dystrophy (RSMD1), the classical form of multiminicore disease, desmin related myopathy with Mallory-body like inclusions, and congenital fiber-type disproportion (CFTD). This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec). Sec is encoded by the UGA codon, which normally signals translation termination. The 3 UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. A second stop-codon redefinition element (SRE) adjacent to the UGA codon has been identified in this gene (PMID:15791204). SRE is a phylogenetically conserved stem-loop structure that stimulates readthrough at the UGA codon, and augments the Sec insertion efficiency by SECIS. Alternatively spliced transcript variants have been found for this gene. |
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25 ug of the indicated Human whole cell or tissue extracts was loaded onto a 12% SDS-PAGE gel. 3 ug/mL of the antibody was used in this experiment. |
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WB Suggested Anti-SEPN1 Antibody Titration: 1 ug/ml Positive Control: Hela cell lysate |
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SEPN1 antibody - C-terminal region (ARP47655_P050) in Human HeLa using Western Blot |
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