SENP6 Antibody - C-terminal region
Catalog Number:
ASB-ARP50600_P050
- Images (3)
| Article Name: | SENP6 Antibody - C-terminal region |
| Biozol Catalog Number: | ASB-ARP50600_P050 |
| Supplier Catalog Number: | ARP50600_P050 |
| Alternative Catalog Number: | ASB-ARP50600_P050-25UL,ASB-ARP50600_P050-100UL |
| Manufacturer: | Aviva |
| Host: | Rabbit |
| Category: | Proteine/Peptide |
| Application: | WB |
| Species Reactivity: | Bovine, Equine, Human, Porcine |
| Immunogen: | The immunogen is a synthetic peptide directed towards the C terminal region of human SENP6 |
| Alternative Names: | SSP1, SUSP1 |
| SENP6 is a UBL-specific protease that deconjugates SUMO1, SUMO2 and SUMO3 from targeted proteins. It does not seem to be involved in the processing of full-length SUMO proteins to their mature forms. SENP6 deconjugates SUMO1 from RXRA, leading to transcriptional activation. It may act preferentially on substrates containing 3 or more SUMO2 or SUMO3 moieties.Ubiquitin-like molecules (UBLs), such as SUMO1 (UBL1, MIM 601912), are structurally related to ubiquitin (MIM 191339) and can be ligated to target proteins in a similar manner as ubiquitin. However, covalent attachment of UBLs does not result in degradation of the modified proteins. SUMO1 modification is implicated in the targeting of RANGAP1 (MIM 602362) to the nuclear pore complex, as well as in stabilization of I-kappa-B-alpha (NFKBIA, MIM 164008) from degradation by the 26S proteasome. Like ubiquitin, UBLs are synthesized as precursor proteins, with 1 or more amino acids following the C-terminal glycine-glycine residues of the mature UBL protein. Thus, the tail sequences of the UBL precursors need to be removed by UBL-specific proteases, such as SENP6, prior to their conjugation to target proteins (Kim et al., 2000 [PubMed 10799485]).[supplied by OMIM]. |
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WB Suggested Anti-SENP6 Antibody Titration: 0.2-1 ug/ml Positive Control: 721_B cell lysateSENP6 is strongly supported by BioGPS gene expression data to be expressed in Human 721_B cells |
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Sample Type: ,1.Rat Testis cells (200ug) , Primary Dilution: ,1:1000 Secondary Antibody: ,alkaline phosphatase-conjugated anti-rabbit Secondary Dilution: ,1:1000 Image Submitted by: ,Andreia Carvalho IBMC-OBF, Portugal ,See Customer Feedback tab for detailed information. |
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SENP6 antibody - C-terminal region (ARP50600_P050) in Human 721_B using Western Blot |
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