ULK1 Antibody - N-terminal region
Catalog Number:
ASB-ARP54261_P050
- Images (3)
| Article Name: | ULK1 Antibody - N-terminal region |
| Biozol Catalog Number: | ASB-ARP54261_P050 |
| Supplier Catalog Number: | ARP54261_P050 |
| Alternative Catalog Number: | ASB-ARP54261_P050-25UL,ASB-ARP54261_P050-100UL |
| Manufacturer: | Aviva |
| Host: | Rabbit |
| Category: | Proteine/Peptide |
| Application: | WB |
| Species Reactivity: | Bovine, Canine, Equine, Guinea pig, Human, Mouse, Rabbit, Rat, Zebrafish |
| Immunogen: | The immunogen is a synthetic peptide directed towards the N-terminal region of Human ULK1 |
| Alternative Names: | ATG1, ATG1A, UNC51, hATG1, Unc51.1 |
| ULK1 is a serine/threonine-protein kinase involved in autophagy in response to starvation. It acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy: acts both as a downstream effector and negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. It is activated via phosphorylation by AMPK and also acts as a regulator of AMPK by mediating phosphorylation of AMPK subunits PRKAA1, PRKAB2 and PRKAG1, leading to negatively regulate AMPK activity. It may phosphorylate ATG13/KIAA0652 and RPTOR, however such data need additional evidences and plays a role early in neuronal differentiation and is required for granule cell axon formation. |
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Host: Rabbit Target Name: ULK1 Sample Type: Thymus Tumor lysates Antibody Dilution: 1.0ug/ml |
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25 ug of the indicated Human whole cell extracts was loaded onto a 12% SDS-PAGE gel. 3 ug/mL of the antibody was used in this experiment. Upper band located above the arrow is phosphorylated form. |
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ULK1 Antibody - N-terminal region (ARP54261_P050) in Human Thymus Tumor using Western Blot |
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