Bovine, Canine, Equine, Guinea pig, Human, Mouse, Porcine, Rat
Immunogen:
The immunogen is a synthetic peptide directed towards the N-terminal region of human JAK3
Alternative Names:
JAKL, LJAK, JAK-3, L-JAK, JAK3_HUMAN
The protein encoded by this gene is a member of the Janus kinase (JAK) family of tyrosine kinases involved in cytokine receptor-mediated intracellular signal transduction. It is predominantly expressed in immune cells and transduces a signal in response to its activation via tyrosine phosphorylation by interleukin receptors. Mutations in this gene are associated with autosomal SCID (severe combined immunodeficiency disease).