Canine, Equine, Guinea pig, Human, Mouse, Rabbit, Rat, Yeast, Zebrafish
Immunogen:
The immunogen is a synthetic peptide directed towards the middle region of human PTPN22
Alternative Names:
LYP, PEP, LYP1, LYP2, PTPN8, PTPN22.5, PTPN22.6
This gene encodes of member of the non-receptor class 4 subfamily of the protein-tyrosine phosphatase family. The encoded protein is a lymphoid-specific intracellular phosphatase that associates with the molecular adapter protein CBL and may be involved in regulating CBL function in the T-cell receptor signaling pathway. Mutations in this gene may be associated with a range of autoimmune disorders including Type 1 Diabetes, rheumatoid arthritis, systemic lupus erythematosus and Graves disease. Alternatively spliced transcript variants encoding distinct isoforms have been described.