ITGB3BP Antibody - N-terminal region
Catalog Number:
ASB-ARP54999_P050
- Images (2)
| Article Name: | ITGB3BP Antibody - N-terminal region |
| Biozol Catalog Number: | ASB-ARP54999_P050 |
| Supplier Catalog Number: | ARP54999_P050 |
| Alternative Catalog Number: | ASB-ARP54999_P050-25UL,ASB-ARP54999_P050-100UL |
| Manufacturer: | Aviva |
| Host: | Rabbit |
| Category: | Proteine/Peptide |
| Application: | WB |
| Species Reactivity: | Human |
| Immunogen: | The immunogen is a synthetic peptide directed towards the N terminal region of human ITGB3BP |
| Alternative Names: | CENPR, NRIF3, TAP20, CENP-R, HSU37139 |
| ITGB3BP is a transcription coregulator that can have both coactivator and corepressor functions. Isoform 1, but not other isoforms, is involved in the coactivation of nuclear receptors for retinoid X (RXRs) and thyroid hormone (TRs) in a ligand-dependent fashion. ITGB3BP acts as a transcriptional corepressor via its interaction with the NFKB1 NF-kappa-B subunit, possibly by interfering with the transactivation domain of NFKB1. It induces apoptosis in breast cancer cells, but not in other cancer cells, via a caspase-2 mediated pathway that involves mitochondrial membrane permeabilization but does not require other caspases. ITGB3BP may also act as an inhibitor of cyclin A-associated kinase. ITGB3BP may be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. |
|
|
WB Suggested Anti-ITGB3BP Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1:62500 Positive Control: MCF7 cell lysate |
|
|
ITGB3BP antibody - N-terminal region (ARP54999_P050) in Human MCF-7 using Western Blot |
Product Guarantee and Expert Support
