NOG Antibody - middle region
Catalog Number:
ASB-ARP58773_P050
- Images (3)
| Article Name: | NOG Antibody - middle region |
| Biozol Catalog Number: | ASB-ARP58773_P050 |
| Supplier Catalog Number: | ARP58773_P050 |
| Alternative Catalog Number: | ASB-ARP58773_P050-25UL,ASB-ARP58773_P050-100UL |
| Manufacturer: | Aviva |
| Host: | Rabbit |
| Category: | Proteine/Peptide |
| Application: | WB |
| Species Reactivity: | Bovine, Canine, Equine, Human, Mouse, Porcine, Rat, Sheep |
| Immunogen: | The immunogen is a synthetic peptide directed towards the middle region of human NOG |
| Alternative Names: | SYM1, SYNS1, SYNS1A |
| The secreted polypeptide, encoded by this gene, binds and inactivates members of the transforming growth factor-beta (TGF-beta) superfamily signaling proteins, such as bone morphogenetic protein-4 (BMP4). By diffusing through extracellular matrices more efficiently than members of the TGF-beta superfamily, this protein may have a principal role in creating morphogenic gradients. The protein appears to have pleiotropic effect, both early in development as well as in later stages. It was originally isolated from Xenopus based on its ability to restore normal dorsal-ventral body axis in embryos that had been artificially ventralized by UV treatment. The results of the mouse knockout of the ortholog suggest that it is involved in numerous developmental processes, such as neural tube fusion and joint formation. Recently, several dominant human NOG mutations in unrelated families with proximal symphalangism (SYM1) and multiple synostoses syndrome (SYNS1) were identified, both SYM1 and SYNS1 have multiple joint fusion as their principal feature, and map to the same region (17q22) as this gene. All of these mutations altered evolutionarily conserved amino acid residues. The amino acid sequence of this human gene is highly homologous to that of Xenopus, rat and mouse. |
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WB Suggested Anti-NOG Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1:312500 Positive Control: ACHN cell lysate |
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Host: Mouse Target Name: NOG Sample Tissue: Mouse Heart Antibody Dilution: 1ug/ml |
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NOG antibody - middle region (ARP58773_P050) in Human ACHN using Western Blot |
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