CASP1 Antibody - middle region
Catalog Number:
ASB-ARP58983_P050
- Images (3)
| Article Name: | CASP1 Antibody - middle region |
| Biozol Catalog Number: | ASB-ARP58983_P050 |
| Supplier Catalog Number: | ARP58983_P050 |
| Alternative Catalog Number: | ASB-ARP58983_P050-25UL,ASB-ARP58983_P050-100UL |
| Manufacturer: | Aviva |
| Host: | Rabbit |
| Category: | Proteine/Peptide |
| Application: | IHC, WB |
| Species Reactivity: | Equine, Human, Rabbit, Yeast |
| Immunogen: | The immunogen is a synthetic peptide directed towards the middle region of human CASP1 |
| Alternative Names: | ICE, P45, IL1BC |
| This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. This gene was identified by its ability to proteolytically cleave and activate the inactive precursor of interleukin-1, a cytokine involved in the processes such as inflammation, septic shock, and wound healing. This gene has been shown to induce cell apoptosis and may function in various developmental stages. Studies of a similar gene in mouse suggest a role in the pathogenesis of Huntington disease. Alternative splicing of this gene results in five transcript variants encoding distinct isoforms. |
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Rabbit Anti-CASP1 Antibody Catalog Number: ARP58983_P050 Formalin Fixed Paraffin Embedded Tissue: Human Lymph Node Tissue Observed Staining: Cytoplasm Primary Antibody Concentration: 1:600 Other Working Concentrations: N/A Secondary Antibody: Donkey anti-Rabbit-Cy3 Secondary Antibody Concentration: 1:200 Magnification: 20X Exposure Time: 0.5 - 2.0 sec |
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WB Suggested Anti-CASP1 Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1:1562500 Positive Control: 721_B cell lysateCASP1 is strongly supported by BioGPS gene expression data to be expressed in Human 721_B cells |
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CASP1 antibody - middle region (ARP58983_P050) in Human 721_B using Western Blot |
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