CYP3A5 Antibody - N-terminal region

Catalog Number: ASB-ARP60135_P050
Article Name: CYP3A5 Antibody - N-terminal region
Biozol Catalog Number: ASB-ARP60135_P050
Supplier Catalog Number: ARP60135_P050
Alternative Catalog Number: ASB-ARP60135_P050-25UL,ASB-ARP60135_P050-100UL
Manufacturer: Aviva
Host: Rabbit
Category: Proteine/Peptide
Application: WB
Species Reactivity: Bovine, Canine, Equine, Guinea pig, Human, Mouse, Porcine, Rat, Sheep
Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human CYP3A5
Alternative Names: CP35, PCN3, CYPIIIA5, P450PCN3
This gene,CYP3A5, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by glucocorticoids and some pharmacological agents. The enzyme metabolizes drugs such as nifedipine and cyclosporine as well as the steroid hormones testosterone, progesterone and androstenedione. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. This cluster includes a pseudogene, CYP3A5P1, which is very similar to CYP3A5. This similarity has caused some difficulty in determining whether cloned sequences represent the gene or the pseudogene. Multiple alternatively spliced transcript variants have been identified for this gene.
Clonality: Polyclonal
Concentration: 0.5 mg/ml
Molecular Weight: 57kDa
NCBI: 1577
UniProt: P51589
Form: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Rabbit Anti-CYP3A5 antibody
Catalog Number: ARP60135
Formalin Fixed Paraffin Embedded Tissue: Human Adult Small intestine
Observed Staining: Cytoplasm in hepatocytes
Primary Antibody Concentration: 1:600
Secondary Antibody: Donkey anti-Rabbit-Cy3
Secondary Antibody Concentration: 1:200
Magnification: 20X
Exposure Time: 0.5 a€'' 2.0 sec
WB Suggested Anti-CYP3A5 Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:62500
Positive Control: Human Placenta
CYP3A5 antibody - N-terminal region (ARP60135_P050) in Human Placenta using Western Blot