Bovine, Equine, Guinea pig, Human, Mouse, Porcine, Rabbit, Rat
Alternative Names:
C6.1A, BRCC36, CXorf53
This gene encodes a subunit of the BRCA1-BRCA2-containing complex (BRCC), which is an E3 ubiquitin ligase. This complex plays a role in the DNA damage response, where it is responsible for the stable accumulation of BRCA1 at DNA break sites. The component encoded by this gene can specifically cleave Lys 63-linked polyubiquitin chains, and it regulates the abundance of these polyubiquitin chains in chromatin. The loss of this gene results in abnormal angiogenesis and is associated with syndromic moyamoya, a cerebrovascular angiopathy.
Host: Rabbit Target Name: BRCC3 Sample Type: Human Hela Antibody Dilution: 1.0ug/mlBRCC3 is strongly supported by BioGPS gene expression data to be expressed in Human HeLa cells
BRCC3 antibody - C-terminal region (ARP61990_P050) in Human Fetal heart using Western Blot
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