NLRP3 Antibody - N-terminal region
Catalog Number:
ASB-ARP63297_P050
- Images (4)
| Article Name: | NLRP3 Antibody - N-terminal region |
| Biozol Catalog Number: | ASB-ARP63297_P050 |
| Supplier Catalog Number: | ARP63297_P050 |
| Alternative Catalog Number: | ASB-ARP63297_P050-25UL,ASB-ARP63297_P050-100UL |
| Manufacturer: | Aviva |
| Host: | Rabbit |
| Category: | Proteine/Peptide |
| Application: | WB |
| Species Reactivity: | Bovine, Canine, Equine, Human, Porcine, Rabbit |
| Alternative Names: | AII, AVP, FCU, MWS, FCAS, KEFH, CIAS1, FCAS1, NALP3, C1orf7, CLR1.1, DFNA34, PYPAF1, AGTAVPRL |
| This gene encodes a pyrin-like protein containing a pyrin domain, a nucleotide-binding site (NBS) domain, and a leucine-rich repeat (LRR) motif. This protein interacts with the apoptosis-associated speck-like protein PYCARD/ASC, which contains a caspase recruitment domain, and is a member of the NALP3 inflammasome complex. This complex functions as an upstream activator of NF-kappaB signaling, and it plays a role in the regulation of inflammation, the immune response, and apoptosis. Mutations in this gene are associated with familial cold autoinflammatory syndrome (FCAS), Muckle-Wells syndrome (MWS), chronic infantile neurological cutaneous and articular (CINCA) syndrome, and neonatal-onset multisystem inflammatory disease (NOMID). |
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WB Suggested Anti-NLRP3 Antibody Titration: 1.0 ug/ml Positive Control: Fetal Kidney |
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Lanes: Lane 1: 30ug human glioma lysate Lane 2: 30ug IL-1 treated human glioma lysate Primary Antibody Dilution: 1:500 Secondary Antibody: Anti-rabbit-HRP Secondary Antibody Dilution: 1:500 Gene Name: NLRP3 Submitted by: Anonymous |
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Surface Plasmon Resonance Kinetic Characterization of Polyclonal Antibody Affinity. Purified polyclonal antibodies were immobilized on a Protein A/G coated Carterra LSA sensor chip (PAGH200M) at concentrations of 5, and 50 ug/mL in duplicate. Antibodies on the surface were exposed to interaction with peptides sequentially via microfluidic controlled flow at 333nM peptide concentration for kinetic characterization of the binders for affinity and specificity, followed by curve fitting using the Kinetics software. Kd determinations for both concentrations were averaged and results and standard deviation are shown. |
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NLRP3 antibody - N-terminal region (ARP63297_P050) in Human Fetal Kidney using Western Blot |
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