WWTR1 Antibody - C-terminal region
Catalog Number:
ASB-ARP74351_P050
- Images (3)
| Article Name: | WWTR1 Antibody - C-terminal region |
| Biozol Catalog Number: | ASB-ARP74351_P050 |
| Supplier Catalog Number: | ARP74351_P050 |
| Alternative Catalog Number: | ASB-ARP74351_P050-25UL,ASB-ARP74351_P050-100UL |
| Manufacturer: | Aviva |
| Host: | Rabbit |
| Category: | Proteine/Peptide |
| Application: | WB |
| Species Reactivity: | Human |
| Immunogen: | The immunogen is a synthetic peptide directed towards the C-terminal region of Human WWTR1 |
| Alternative Names: | TAZ |
| WWTR1 is a transcriptional coactivator which acts as a downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. WWTR1 enhances PAX8 and NKX2-1/TTF1-dependent gene activation. It regulates the nuclear accumulation of SMADS and has a key role in coupling them to the transcriptional machinery such as the mediator complex. And it regulates embryonic stem-cell self-renewal, promotes cell proliferation and epithelial-mesenchymal transition. |
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Host: Rabbit Target Name: WWTR1 Sample Type: 786-0 Whole Cell lysates Antibody Dilution: 1.0ug/ml |
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Host: Mouse Target Name: WWTR1 Sample Tissue: Mouse Testis Antibody Dilution: 1ug/ml |
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WWTR1 Antibody (ARP74351_P050) in Human 786-0 Whole Cell using Western Blot |
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