CRK Antibody - middle region
Catalog Number:
ASB-ARP74457_P050
- Images (3)
| Article Name: | CRK Antibody - middle region |
| Biozol Catalog Number: | ASB-ARP74457_P050 |
| Supplier Catalog Number: | ARP74457_P050 |
| Alternative Catalog Number: | ASB-ARP74457_P050-25UL,ASB-ARP74457_P050-100UL |
| Manufacturer: | Aviva |
| Host: | Rabbit |
| Category: | Proteine/Peptide |
| Application: | WB |
| Species Reactivity: | Human |
| Immunogen: | The immunogen is a synthetic peptide directed towards the middle region of human CRK |
| Alternative Names: | p38, CRKII |
| This gene encodes a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. The product of this gene has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Two alternative transcripts encoding different isoforms with distinct biological activity have been described. |



