IKZF1 Antibody - middle region
Catalog Number:
ASB-ARP74585_P050
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| Article Name: | IKZF1 Antibody - middle region |
| Biozol Catalog Number: | ASB-ARP74585_P050 |
| Supplier Catalog Number: | ARP74585_P050 |
| Alternative Catalog Number: | ASB-ARP74585_P050-25UL,ASB-ARP74585_P050-100UL |
| Manufacturer: | Aviva |
| Host: | Rabbit |
| Category: | Proteine/Peptide |
| Application: | WB |
| Species Reactivity: | Human |
| Immunogen: | The immunogen is a synthetic peptide directed towards the middle region of human IKZF1 |
| Alternative Names: | IK1, LYF1, LyF-1, CVID13, IKAROS, PPP1R92, PRO0758, ZNFN1A1, Hs.54452 |
| This gene encodes a transcription factor that belongs to the family of zinc-finger DNA-binding proteins associated with chromatin remodeling. The expression of this protein is restricted to the fetal and adult hemo-lymphopoietic system, and it functions as a regulator of lymphocyte differentiation. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene. Most isoforms share a common C-terminal domain, which contains two zinc finger motifs that are required for hetero- or homo-dimerization, and for interactions with other proteins. The isoforms, however, differ in the number of N-terminal zinc finger motifs that bind DNA and in nuclear localization signal presence, resulting in members with and without DNA-binding properties. Only a few isoforms contain the requisite three or more N-terminal zinc motifs that confer high affinity binding to a specific core DNA sequence element in the promoters of target genes. The non-DNA-binding isoforms are largely found in the cytoplasm, and are thought to function as dominant-negative factors. Overexpression of some dominant-negative isoforms have been associated with B-cell malignancies, such as acute lymphoblastic leukemia (ALL). |
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Host: Rabbit Target Name: IKZF1 Sample Tissue: Stomach Tumor lysates Antibody Dilution: 1ug/ml |
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Host: Mouse Target Name: IKZF1 Sample Tissue: Mouse Pancreas Antibody Dilution: 1ug/ml |
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IKZF1 Antibody - middle region (ARP74585_P050) in Human Stomach Tumor using Western Blot |
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