UIMC1 Antibody - middle region
Catalog Number:
ASB-ARP75596_P050
- Images (4)
| Article Name: | UIMC1 Antibody - middle region |
| Biozol Catalog Number: | ASB-ARP75596_P050 |
| Supplier Catalog Number: | ARP75596_P050 |
| Alternative Catalog Number: | ASB-ARP75596_P050-25UL,ASB-ARP75596_P050-100UL |
| Manufacturer: | Aviva |
| Host: | Rabbit |
| Category: | Proteine/Peptide |
| Application: | WB |
| Species Reactivity: | Human |
| Immunogen: | The immunogen is a synthetic peptide directed towards the middle region of Human UIMC1 |
| Alternative Names: | RAP80, X2HRIP110 |
| UIMC1 is a ubiquitin-binding protein that specifically recognizes and binds Lys-63-linked ubiquitin. It plays a central role in the BRCA1-A complex by specifically binding Lys-63-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes Lys-63-linked ubiquitin on histones H2A and H2AX. It also weakly binds monoubiquitin but with much less affinity than Lys-63-linked ubiquitin. It may interact with monoubiquitinated histones H2A and H2B, the relevance of such results is however unclear in vivo. Does not bind Lys-48-linked ubiquitin. And it may indirectly act as a transcriptional repressor by inhibiting the interaction of NR6A1 with the corepressor NCOR1. |
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Host: Rabbit Target Name: UIMC1 Sample Type: MCF7 Whole Cell lysates Antibody Dilution: 1.0ug/ml |
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Host: Rabbit Target Name: UIMC1 Sample Tissue: Human HCT116 Whole Cell Antibody Dilution: 1ug/ml |
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Host: Rabbit Target Name: UIMC1 Sample Tissue: Human 293T Whole Cell Antibody Dilution: 1ug/ml |
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UIMC1 Antibody (ARP75596_P050) in Human MCF7 Whole Cell using Western Blot |
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